The 27 Best NFL Prop Bets 27 Days Out From Preseason

• The San Francisco 49ers have +4000 odds to win all six division games but lost four of them during the 2021 season.
• The Buffalo Bills have +400 odds to start the season 4-0 after doing it in 2020 and were one win away in both 2021 and 2019.

LOS ANGELES – The NFL Preseason is only 27 days away, meaning the first regular-season game at Sofi Stadium against the Super Bowl favorite Bills is imminent.

To prepare for the season, there are 27 prop bets for the 2021-2022 season that have betting value.

Oddsmakers have the Bills as the favorite to have the most wins for the 2022 season, after going 11-6 in 2021, with the Texans having the worse record, after going 4-11.

During the 2021 season, the Bills went 5-1 for their division’s games, only losing in New England, with 27 mph winds.

The 2020 season started with the Bills going 4-0 but the Bills started 3-1 for both the 2019 and 2021 seasons. The have to start 2022 with the LA Rams.

During the 2021 season, the Bills played nine home games and only lost three of them. The season before that, they only suffered one single home loss.

Only losing three road games in 2021, another three in 2020, and two in 2019, the Bills have shown their ability to win in any environment. Sportsbooks are favoring the to make it.

The Bills have not missed the playoffs since 2018, Josh Allen’s rookie year under center when the team had +900 odds to make them.

Being in the only division that produced three playoff teams last season, the Cardinals went 4-2 against other NFC West teams, losing to the Rams and the Seahawks both at home.

The Cardinals had no issues starting the season 7-0 in 2021.

After winning their first three, the Cardinals ended up dropping five total home games during the 2021 season.

The only road game the Cardinals lost during the 2021 season was against the Detroit Lions in Week 15, for their second win of the season.

Missing the playoffs from 2016-2020 with favored odds to miss, the Cardinals made the playoffs in 2021 with +165 odds.

The Colts went 3-3 in divisional play in 2021 but now have starting QB Matt Ryan, while the Titans lost top wide receiver, AJ Brown.

The Colts started last season with Carson Wentz and went 1-3, but for 2022, they have Matt Ryan and still one of the best running backs in the league in Jonathan Taylor.

The Colts were not exactly strong from home last year, with five total losses, one of them being in overtime.

During the 2021 season, the Colts were stronger on the road than at home, going 5-3, bringing value to their odds for winning on the road.

Last season, the Colts had -210 preseason odds to make the playoffs and were only one Jacksonville Jaguars win away from doing so.

The 49ers lost four of their six division games last year, the only two wins were against the Los Angeles Rams.

Starting the season 2-2, the 49ers two wins in that stretch were from the Lions and Eagles.

San Francisco went 4-4 in 2021 and 1-7 in 2020, when playing at home.

Going 6-3 on the road in 2021, the 49ers showed that they played better on the road than in their stadium.

San Francisco had -330 preseason odds to make the playoffs during the 2020 season but ended up falling short.

All three of these teams have made the playoffs multiple times in the last few years, with the Ravens barely missing the cut last year, playing with a backup QB.

The Eagles were the only of these teams to make it to the 2021 playoffs, but have all undergone significant roster upgrades, and the Saints have a healthy Winston, who had a 2021 5-2 record before the injury.

This bet has value depending on Deshaun Watson and could be put in the back pocket until the NFL announces their decision on a season suspension.

The 2008 Detroit Lions and the 2017 Cleveland Browns both endured winless seasons, with the Lions coming close in 2021, with little to no roster improvement for the 2022 season.

The 2007 New England Patriots and the 1972 Miami Dolphins are the only two teams to ever go undefeated in the NFL regular season.