Broncos vs 49ers Betting Odds NFL Week 4

• The San Francisco 49ers are 2.5-point favorites against the Denver Broncos.
• There is a 48-point total set between the 49ers and Broncos.

SAN FRANCISCO – In the late afternoon window, the Denver Broncos are on the road against the San Francisco 49ers at Levi’s Stadium. San Francisco comes in undefeated at 3-0 with a 2-0 record at home, while the Broncos are 2-1 with their loss coming on the road.

Super Bowl sportsbooks are laying the points on the Niners given their strengths on both sides of the ball. While oddsmakers are only slightly leaning on the 49ers with 2.5 points, there is reason to believe they could run with this one beyond the spread.

Denver Broncos vs San Francisco 49ers

• Moneyline: Broncos (+125) vs. 49ers (-145)
• Spread: 49ers -2.5 (-120)
• Total: 48

Take Advantage of Discounted 49ers Spread

This is a discounted spread on California sportsbooks on the Niners. The 49ers come into this one undefeated outright and 2-1 against the spread with a +10.3-point cover margin on average. They are 3-0 against a 2.5-point spread. On the other hand, Denver is also 2-1, however, their lone loss against the spread came against the Kansas City Chiefs as a +2.5-point underdog.

The numbers on both sides of the ball also speak for themselves in favor of San Francisco. The Niners have a -6.6 advantage on defense in terms of points allowed and a +12.7 scoring advantage on offense.

It also doesn’t help their case that San Francisco is fifth in the league in total yards with 399.3, and Denver allows the fourth most yards on defense at 380.7. The 49ers are also tied with the Buffalo Bills for the most total touchdowns in the league with 13.